SYNONYMS
Cystatin-SA-III, Cystatin-4, cystatin S, Salivary acidic protein 1.
INTRODUCTION
CST4 is a member of the cystatin superfamily which contains proteins that hold multiple cystatin-like sequences. Several family members are active cysteine protease inhibitors, whereas others have lost or possibly never attained this inhibitory activity. CST4 strongly inhibits papain (non-competitively) and ficin, partially inhibits stem bromelain and bovine cathepsin C, however does not inhibit porcine cathepsin B or clostripain.
DESCRIPTION
CST4 Human Recombinant produced in E. coli is a single polypeptide chain containing 145 amino acids (21-141) and having a molecular mass of 16.8kDa.
CST4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
