PRPS1

SYNONYMS
ARTS, CMTX5, PPRibP, PRSI, DFN2, Ribose-phosphate pyrophosphokinase 1, DFNX1, Phosphoribosyl pyrophosphate synthase I, PRS-I, PRPS1, KIAA0967.

TYPE
Mouse Anti Human Monoclonal.

INTRODUCTION
PRPS1 catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. PRPS1 catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is essential for purine metabolism and nucleotide biosynthesis. Defects in PRPS1 result in phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.

CLONE
PAT1E11AT.

PHYSICAL APPEARANCE
Sterile filtered colorless solution.

IMMUNOGEN
Anti-human PRPS1 mAb, clone PAT1E11AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PRPS1 protein 1-318 amino acids purified from E. coli.

IG SUBCLASS
Mouse IgG2a heavy chain and k light chain.

PURIFICATION METHOD
PRPS1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.

FORMULATION
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.

STORAGE PROCEDURES
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. 
Prevent freeze thaw cycles.

STABILITY / SHELF LIFE
12 months at -20°C. 1 month at 4°C.

APPLICATIONS
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

SAFETY DATA SHEET
SDS

USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

https://www.prospecbio.com/prps1_antibody