SYNONYMS
Macrosialin, CD68, Gp110, Macrosialin isoform A, GP110, LAMP4, SCARD1.
INTRODUCTION
CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
DESCRIPTION
CD68 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 307 amino acids (22-319) and having a molecular mass of 32.6kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).
CD68 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
