SYNONYMS
T Lymphocyte Surface Glycoprotein Beta Chain, CD8 Antigen, Beta Polypeptide 1 (P37), CD8b Molecule, CD8b Antigen, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8B1, LYT3, LY3, LEU2, P37.
INTRODUCTION
CD8B encodes the CD8 beta chain isoforms of the CD8 antigen. CD8 is a cell surface glycoprotein which facilitates efficient cell-cell interactions within the immune system and is located on most cytotoxic T lymphocytes. The T-cell receptor on the T lymphocyte and the co-receptor CD8 antigen identify antigens exposed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional co-receptor is either a heterodimer composed of one alpha and one beta chain or a homodimer composed of two alpha chains. Both alpha and beta chains share substantial homology to immunoglobulin variable light chains.
DESCRIPTION
CD8B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 172 amino acids (22-170) and having a molecular mass of 19.2 kDa. CD8B is fused to a 23 amino acid His-tag at N-terminus.
