PPM1D

SYNONYMS
Protein phosphatase 1D magnesium-dependent, delta isoform, PPM1D, Protein Phosphatase 1D, PP2C-DELTA, WIP1.

INTRODUCTION
Protein Phosphatase 1D (PPM1D) belongs to the PP2C family of Ser/Thr protein phosphatases whose members are negative regulators of cell stress response pathways. PPM1D is induced by tumor suppressor protein TP53/p53 in response to multiple environmental stresses. PPM1D is a negative regulator of the activity of p38 MAP kinase through which it reduces the phosphorylation of p53 and suppresses p53-mediated transcription and apoptosis. PPM1D is located in a chromosomal area which enlarges in breast cancer.

DESCRIPTION
PPM1D Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 299 amino acids (98-375a.a.) and having a molecular mass of 33.2kDa.
PPM1D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

https://www.prospecbio.com/ppm1d_human