SYNONYMS
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, Aminoacylase 1, Acy1.
INTRODUCTION
Acy1 or Aminoacylase1 is a cytosolic, homodimeric, zinc-binding enzyme which catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been suggested to operate in the catabolism and salvage of acylated amino acids. ACY1 is localized in chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been observed to be reduced or undetectable in SCLC cell lines and tumors.
DESCRIPTION
ACY1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-408 a.a) and having a molecular mass of 48.4kDa.
ACY1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
