mGDNF

SYNONYMS
ATF1, ATF2, HFB1-GDNF, GDNF.

INTRODUCTION
GDNF promotes the survival and differentiation of  neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
GDNF enhances survival and morphological differentiation of  neurons and increases their high-affinity uptake.

DESCRIPTION
Glial derived Neurotrophic Factor Mouse Recombinant produced in E.Coli is a non-glycosylated homodimer containing 2 x 135 amino acids and having a total molecular mass of 30.2kDa.
GDNF is purified by proprietary chromatographic techniques.

https://www.prospecbio.com/gdnf_mouse