SYNONYMS
Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, EC 3.6.1.52, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, Nucleoside diphosphate-linked moiety X motif 4, NUDT4, DIPP2, KIAA0487, HDCMB47P, DIPP2beta, DIPP2alpha.
INTRODUCTION
Nudix Type Motif 4 (NUDT4) regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates exemplifies a molecular switching activity with significant regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may be a factor in regulating intracellular trafficking.
DESCRIPTION
NUDT4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-180 a.a) and having a molecular mass of 22.7kDa.
NUDT4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
