SYNONYMS
Chitinase 3-like 1, CHI3L1, Chitinase-3-like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39, CGP-39, GP-39, hCGP-39.
INTRODUCTION
Chitinase 3-Like 1 (CHI3L1) catalyze the hydrolysis of chitin that is an abundant glycopolymer present in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases comprises 8 human family members. CHI3L1 belongs to the glycosyl hydrolase 18 family. CHI3L1 lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 takes part in the process of inflammation and tissue remodeling.
DESCRIPTION
CHI3L1 Human Recombinant produced in CHO is a single, glycosylated polypeptide chain containing 408 amino acids (1-383) and having a molecular mass of 45.5kDa. CHI3L1 is fused to a 25 amino acid myc-His-tag at C-terminus & purified by proprietary chromatographic techniques.
