SYNONYMS
Adenosine deaminase, Adenosine aminohydrolase, ADA1, EC 3.5.4.4.
INTRODUCTION
ADA catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. ADA has a vital part in purine metabolism and in adenosine homeostasis. ADA performs as a positive regulator of T-cell coactivation, by binding DPP4 which regulates lymphocyte-epithelial cell adhesion.
DESCRIPTION
ADA Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 383 amino acids (1-363) and having a molecular mass of 42.9 kDa.
The ADA is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
