GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Leptin (LEP)
Homolog of Murine Obesity (OB, OBS)
Human Leptin is a hormone expressed and secreted primarily by adipose tissues, though also produced by a variety of other cells at lower levels. It is a ligand for the leptin receptor (LEPR) that is expressed at highest levels in the hypothalamus. Leptin’s primary role is in the regulation of energy balance in the body, stimulating energy expenditure while inhibiting hunger. It inhibits the activity of neuropeptide Y and downregulates the expression of endocannabinoids, while upregulating expression of α-melanocyte-stimulating hormone. Obesity is correlated with a receptor desensitization to leptin that leaves the eater hungry despite high energy stores. Leptin also plays a role in hematopoiesis, angiogenesis, ossification, inflammation, and immune responses.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~16.0 kDa (146 amino acids)
Purity: >97% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of >5.0×105 IU/mg.
Storage/Handling: Store desiccated at -20°C.
HGNC: 6553
NOT FOR HUMAN USE!
https://www.goldbio.com/product/6698/leptin-human
