PDX-1

SYNONYMS
IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1.

TYPE
Polyclonal Rabbit Antibody.

INTRODUCTION
PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.

IMMUNOGEN
Recombinant PDX1 E.Coli derived.

SPECIFICITY
Human and Mouse PDX-1.

MOLECULAR WEIGHT
35-40 kDa.

STABILITY
Stable for 2 yeas at -20°C. Avoid freeze/thaw cycles.

APPLICATIONS
Western Blot: 1:1,000
Immunohistochemistry: 1:500
Optimal working dilutions must be determined by end user.
Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1

SAFETY DATA SHEET
SDS

USAGE
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

https://www.prospecbio.com/pdx-1_antibody