SYNONYMS
MYC, CMYC, C-MYS, V-MYC, P64.
TYPE
Mouse Anti Human Monoclonal.
INTRODUCTION
c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
CLONE
NYRhc-myc.
IMMUNOGEN
synthetic peptides.
IG SUBCLASS
mouse IgG1.
PURIFICATION METHOD
Protein A.
FORMULATION
1mg/ml in PBS (after reconstitution).
STORAGE PROCEDURES
Antibody is shipped lyophilized at ambient temperature.
SOLUBILITY
Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
TITER
By Western blot 1:2,000 dilution will yield a strong band in WB.
SAFETY DATA SHEET
SDS
NOTE
This antibody was produced in BALB/c mice.
USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
