SYNONYMS
Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.
INTRODUCTION
CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.
DESCRIPTION
CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 455 amino acids (26-238a.a.) and having a molecular mass of 50.4kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).
CD200R1 is expressed with a 239 amino acid hIgG His tag at C-Terminus and purified by proprietary chromatographic techniques.
