SYNONYMS
C1q/MBL/SPA receptor, C1qR(p), C1qRp, Cell surface antigen AA4, Complement, component 1 q subcomponent receptor 1, Lymphocyte antigen 68, Ly-68, CD93, Cd93.
INTRODUCTION
CD93, is a receptor or else an element of a larger receptor complex for C1q, MBL2-mannose-binding lectin and SPA-pulmonary surfactant protein A. CD93 mediates the enhancement of phagocytosis in monocytes as well as macrophages upon interaction with soluble defense collagens. CD93 takes part in the intercellular adhesion. Furthermore, CD93 was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells which demonstrated decreased cell cycle activity, high levels of isotype-switched Ig secretion, as well as modification of the transcriptional network. CD93 is vital for the maintenance of plasma cells in bone marrow niches.
DESCRIPTION
CD93 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 558 amino acids (23-572a.a.) and having a molecular mass of 60.1kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). CD93 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
