SYNONYMS
CD19 Molecule, B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12, Differentiation Antigen CD19, CD19 Antigen, B-Lymphocyte Antigen CD19, CVID3, B4.
INTRODUCTION
CD19, also known as B-Lymphocyte Surface Antigen B4, belongs to the Ig superfamily which is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells. CD19 is involved as a signal-transducing receptor in the control of differentiation as well as proliferation. CD19 is as an adaptor protein which drafts cytoplasmic signaling proteins to the membrane and operates within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. CD19 is present on all B cells, and therefore is a biomarker for lymphoma diagnosis, B lymphocyte development and can be used as a target for leukemia immunotherapies.
DESCRIPTION
CD19 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 510 amino acids (21-291a.a.) and having a molecular mass of 57.0kDa. (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).
CD19 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
