SYNONYMS
Antigen-presenting glycoprotein CD1d, R3G1, CD antigen: CD1d, Differentiation Antigen CD1-Alpha-3, T-Cell Surface Glycoprotein CD1d, Thymocyte Antigen CD1D, CD1A, R3, CD1d Molecule, CD1D Antigen, D Polypeptide, CD1d Antigen, R3G1, HMC Class I, Antigen-Like Glycoprotein CD1D, Antigen-Presenting Glycoprotein CD1d.
INTRODUCTION
CD1D, also known as antigen-presenting glycoprotein CD1d, is a transmembrane glycoprotein which belongs to the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1d-presented lipid antigens activate a special class of T cells, familiar as natural killer T (NKT) cells, during the interaction with the T-cell receptor present on NKT membranes. Once activated, NKT cells rapidly produce Th1 &Th2 cytokines, usually represented by interleukin 4 production.
DESCRIPTION
CD1D produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 290 amino acids (20-301 a.a.) and having a molecular mass of 32.9kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
CD1Dis expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
