SKU : pro-632
Recombinant Human B-Cell Leukemia/Lymphoma 2 -BH2
Categories : Prospec ,
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SYNONYMS
Apoptosis regulator Bcl-2, BCL2, B-cell CLL/lymphoma 2, Bcl-2.
INTRODUCTION
BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
DESCRIPTION
Bcl-2 Des BH2 domain (187-202 residues) Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 202 amino acids 1-186 and 203-218.
The Bcl-2 is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques.
