mPGK1

SYNONYMS
Phosphoglycerate kinase 1 (EC:2.7.2.3), Pgk1, Pgk-1.

INTRODUCTION
PGK1 is an X-linked enzyme that has a major role in the glycolytic pathway. PGK1 is a glycolytic enzyme which catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating an ATP molecule. PGK1 may also act as a cofactor for polymerase alpha. Defects in the PGK1 gene are usually associated with chronic hemolytic anemia, though it can be accompanied by either mental retardation or muscular disease (rhabdomyolysis). Overexpression of PGK1 and its signalling targets are possibly an expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination. It was shown that PGK1 is differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

DESCRIPTION
PGK1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 441 amino acids (1-417 a.a) and having a molecular mass of 47.1kDa.
PGK1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

https://www.prospecbio.com/pgk1_mouse